Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding-Reference-Cited by-同舟云学术

Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding

Published:2017 Issue:21 Volume:15 Page:4522-4526
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Balazy Milena¹²³⁴,Fausto Alejandra¹²³⁴,Voskanian Christina¹²³⁴,Chavez Bianca¹²³⁴^ORCID,Panesar Harmanpreet¹²³⁴,Minehan Thomas G.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. California State University

3. Northridge

4. USA

Abstract

Compound1d(K_app= 2.4 × 10⁷M⁻¹), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding.

Funder

American Chemical Society Petroleum Research Fund

Division of Chemistry

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00944E

Reference32 articles.

1. Sequence-Selective DNA Recognition: Natural Products and Nature’s Lessons

2. Natural product DNA major groove binders

3. DNA Binding and Alkylation by the “Left Half” of Azinomycin B

4. Studies on the Mechanism of Action of Azinomycin B: Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate

5. Truncated azinomycin analogues intercalate into DNA

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