Mechanism of non-phenolic substrate oxidation by the fungal laccase Type 1 copper site from Trametes versicolor: the case of benzo[a]pyrene and anthracene

Author:

Orlando Carla12ORCID,Rizzo Isabella Cecilia1,Arrigoni Federica1ORCID,Zampolli Jessica1,Mangiagalli Marco1,Di Gennaro Patrizia1,Lotti Marina1,De Gioia Luca1,Marino Tiziana2ORCID,Greco Claudio3ORCID,Bertini Luca1ORCID

Affiliation:

1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy

2. Department of Chemistry and Chemical Technologies, Università della Calabria, Ponte Pietro Bucci, cubo 14c, 87036 Rende, CS, Italy

3. Department of Earth and Environmental Sciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milano, Italy

Abstract

The reactivity of laccases towards non-phenolic polycyclic aromatic hydrocarbons remains unclear. Using molecular modelling the oxidation of anthracene and benzo[a]pyrene by Trametes versicolor fungal laccase is investigated.

Funder

Ministero dell'Istruzione e del Merito

Publisher

Royal Society of Chemistry (RSC)

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