Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants

Author:

Lin Yu-Chien12ORCID,Hu Chih-Chien345,Liu Wai-Ching6ORCID,Dhawan Udesh7,Chen Yu-Chieh1,Lee Yueh-Lien8,Yen Hung-Wei9,Kuo Yi-Jie1011,Chung Ren-Jei112ORCID

Affiliation:

1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), No. 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan

2. School of Materials Science and Engineering, Nanyang Technological University, Singapore

3. Bone and Joint Research Center, Chang Gung Memorial Hospital, Linko, Taiwan

4. Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Linko, Taiwan

5. College of Medicine, Chang Gung University, Taoyuan, Taiwan

6. Department of Food and Health Sciences, Technological and Higher Education Institute of Hong Kong, New Territories, Hong Kong, China

7. Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow, UK

8. Department of Engineering Science and Ocean Engineering, National Taiwan University, Taipei, Taiwan

9. Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan

10. Department of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

11. Department of Orthopedic Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

12. High-value Biomaterials Research and Commercialization Center, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan

Abstract

The hydrogenated CoCrMo femoral implant, fabricated by the electrochemical cathodic charging method, aims to deliver H2, reducing reactive oxygen species, lessening inflammation, and enhancing osseointegration.

Funder

National Taipei University of Technology

National Science and Technology Council of Taiwan

Chang Gung Memorial Hospital

Publisher

Royal Society of Chemistry (RSC)

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