Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal <i>Salmonella</i> (iNTS)-Reference-Cited by-同舟云学术

Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS)

Published:2023 Issue:8 Volume:4 Page:600-612
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Tsai Caressa N.¹²,Massicotte Marie-Ange¹²,MacNair Craig R.¹²,Perry Jordyn N.¹,Brown Eric D.¹²^ORCID,Coombes Brian K.¹²³^ORCID

Affiliation:

1. Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada

2. Michael G. DeGroote Institute for Infectious Disease Research, Hamilton, ON, Canada

3. Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada

Abstract

Invasive non-typhoidal Salmonella (iNTS) are a growing bacterial threat due to their antimicrobial resistance. This work demonstrates that iNTS are susceptible to host-directed therapies that inhibit intracellular bacterial replication.

Funder

Canadian Institutes of Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00014A

Reference50 articles.

1. Patterns of genome evolution that have accompanied host adaptation inSalmonella

2. Oxidative stress activates transcription of Salmonella pathogenicity island-2 genes in macrophages

3. Multiple histidines in the periplasmic domain of theSalmonella entericasensor kinase SsrA enhance signaling in response to extracellular acidification

4. Machine learning identifies signatures of host adaptation in the bacterial pathogen Salmonella enterica

5. Epidemics of InvasiveSalmonella entericaSerovar Enteritidis andS. entericaSerovar Typhimurium Infection Associated with Multidrug Resistance among Adults and Children in Malawi