Designed ankyrin repeat proteins for detecting prostate-specific antigen expression <i>in vivo</i>-Reference-Cited by-同舟云学术

Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo

Published:2023 Issue:7 Volume:4 Page:494-505
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Gut Melanie¹^ORCID,Dreier Birgit²^ORCID,Furler Sven²,Sobek Jens³^ORCID,Plückthun Andreas²^ORCID,Holland Jason P.¹^ORCID

Affiliation:

1. University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland

2. University of Zurich, Department of Biochemistry, Winterthurerstrasse 190, 8057 Zurich, Switzerland

3. Functional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH) Zurich and University of Zurich, Zurich, Switzerland

Abstract

Prostate specific antigen binding Designed Ankyrin Repeat Proteins (DARPins) were selected and C-terminally conjugated for Gallium-68 radiolabelling. Two of the developed tracers showed specific uptake in mouse prostate tumour models.

Funder

Swiss Cancer Research Foundation

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00010A

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