Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase-Reference-Cited by-同舟云学术

Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase

Published:2023 Issue:10 Volume:21 Page:2086-2090
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Ming-Zhu¹,Chen Kai-Yue¹,Zhang Yi-Bin¹,Zhang Chang-Xuan¹,Xiang Zheng¹²³^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

2. Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China

3. AI for Science (AI4S) Preferred Program, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Abstract

The asymmetric conjugate addition of diethyl malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase was developed and used in the chemoenzymatic synthesis of (+)-femoxetine.

Funder

Shenzhen Science and Technology Innovation Program

Special Project for Research and Development in Key areas of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00111C

Reference50 articles.

1. Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

2. Biocatalysis: Enzymatic Synthesis for Industrial Applications