Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells-Reference-Cited by-同舟云学术

Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells

Published:2020 Issue:9 Volume:2 Page:3942-3953
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Ortiz-Otero Nerymar¹²³⁴,Marshall Jocelyn R.¹²³⁴,Lash Bradley W.⁵⁶⁴,King Michael R.⁷⁸⁹⁴^ORCID

Affiliation:

1. Meinig School of Biomedical Engineering

2. Cornell University

3. Ithaca

4. USA

5. Lehigh Valley Health Network

6. Allentown

7. Department of Biomedical Engineering

8. Vanderbilt University

9. Nashville

Abstract

Liposomal formulation to deliver TNF-related apoptosis-inducing ligand (TRAIL) to platelets via von Willebrand Factor (vWF) interaction. TRAIL-coated platelets killed circulating tumor cells (CTCs) in the bloodstream to reduce cancer metastasis.

Funder

Office of Extramural Research, National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NA/D0NA00271B

Reference35 articles.

1. Adhesion receptors as therapeutic targets for circulating tumor cells

2. Emerging Biological Principles of Metastasis

3. Microenvironmental regulation of tumor progression and metastasis

4. Influence of tumour micro-environment heterogeneity on therapeutic response

5. Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

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