Sustained delivery of gemcitabine via in situ injectable mussel-inspired hydrogels for the local therapy of pancreatic cancer

Author:

Xu Li1,Tang Shengnan2,Yang Huiquan3,Liang Min1ORCID,Ren Pengfei1,Wei Dandan1,He Jian2,Kong Weiwei4,Liu Peidang35,Zhang Tianzhu1ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

2. Department of Nuclear Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

3. School of Medicine, Southeast University, Nanjing 210009, China

4. The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China

5. Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210096, China

Abstract

A desirable therapeutic strategy has been designed and optimized for the localized drug delivery system in vitro and in vivo against pancreatic cancer cells, having the highest possible deceleration of tumor growth with the minimum use of doses.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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