A chlorin-lipid nanovesicle nucleus drug for amplified therapeutic effects of lung cancer by internal radiotherapy combined with the Cerenkov radiation-induced photodynamic therapy

Author:

Cai Pengju12345,Yang Wenjiang62345,He Zhesheng12345,Jia Huiju12345,Wang Huangwei12345,Zhao Wencong12345,Gao Liang7895,Zhang Zhiyong12345,Gao Fuping12345ORCID,Gao Xueyun7895ORCID

Affiliation:

1. CAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety

2. Institute of High Energy Physics

3. Chinese Academy of Sciences

4. Beijing 100049

5. China

6. CAS Key Laboratory of Nuclear Radiation and Nuclear Energy Technology

7. Department of Chemistry and Chemical Engineering

8. Beijing University of Technology

9. Beijing 100124

Abstract

131I-BSA loaded chlorin-lipid nanovesicle constructed from Ce6 and LPPC conjugates for synergistic therapeutic effects of lung cancer by radiotherapy of 131I combined with Cerenkov Radiation (CR)-induced photodynamic therapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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