Efficient catalyst for tandem solvent free enantioselective Knoevenagel-formal [3+3] cycloaddition and Knoevenagel-hetero-Diels

Efficient catalyst for tandem solvent free enantioselective Knoevenagel-formal [3+3] cycloaddition and Knoevenagel-hetero-Diels–Alder reactions

Published:2015 Issue:83 Volume:5 Page:67706-67711
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Fernandes Sylvia¹²³⁴⁵,Rajakannu P.⁶⁷⁸⁵,Bhat Sujata V.¹²³⁴⁵

Affiliation:

1. Laboratory for Advanced Research in Natural and Synthetic Chemistry

2. V. G Vaze College

3. Mumbai University

4. Mumbai 400 081

5. India

6. Department of Chemistry

7. Indian Institute of Technology

8. Mumbai 400 076

Abstract

Tandem Knoevenagel-cycloaddition reactions forming bicyclic tetrahydro-2H-chromen-5(6H)-ones and tricyclic octahydro-2H-benzo[c]-chromen-1(6H)-ones are achieved with up to 98.8% ee in the presence of chiral LBA and titanium-isopropoxy-(S)-BINOLate.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA09865C

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