Supramolecular delivery of dinuclear ruthenium and osmium MCU inhibitors

Author:

Bigham Nicholas P.1ORCID,Novorolsky Robyn J.23,Davis Keana R.4ORCID,Zou Haipei15ORCID,MacMillan Samantha N.1ORCID,Stevenson Michael J.4ORCID,Robertson George S.236ORCID,Wilson Justin J.15ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA

2. Department of Pharmacology, Faculty of Medicine, Dalhousie University, 6th Floor Sir Charles Tupper Medical Building, Halifax, B3H 4R2, Canada

3. Brain Repair Centre, Faculty of Medicine, Dalhousie University, Life Sciences Research Institute, Halifax, NS, B3H 4R2, Canada

4. Department of Chemistry, University of San Francisco, San Francisco, CA, 94117, USA

5. Department of Chemistry & Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106, USA

6. Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 2E2, Canada

Abstract

The mitochondrial calcium uniporter (MCU) inhibitors Ru265 and Os245 were functionalized with adamantane to make them amenable for encapsulation in cucurbituril. The resulting host–guest complexes were investigated for their biological properties.

Funder

Cornell University

Division of Chemistry

University of San Francisco

Heart and Stroke Foundation of Canada

Dalhousie University

National Center for Advancing Translational Sciences

Publisher

Royal Society of Chemistry (RSC)

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