Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

Author:

Alinezhad Vajihe1,Esmaeilzadeh Kimia2,Bagheri Hadi3,Zeighami Habib4,Kalantari-Hesari Ali5,Jafari Rahim2,Makvandi Pooyan6ORCID,Xu Yi7,Mohammadi Hamidreza89,Shahbazi Mohammad-Ali1011,Maleki Aziz13ORCID

Affiliation:

1. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran

2. Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

3. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan 45139-56184, Iran

4. Department of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran

5. Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamadan 6516738695, Iran

6. School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh, EH9 3JL, UK

7. Department of Science & Technology, Department of Urology, Nano Medical Innovation & Collaboration Group (NMICG), The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China

8. Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran

9. Department of Toxicology/Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

10. Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

11. W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Abstract

This study presents a novel photothermally active hydrogel that contains platelet-rich plasma for infected wound healing. The hydrogel showed antibacterial, antioxidant, and hemostatic properties, as well as sustained growth factor release.

Funder

Zanjan University of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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