Studies on the synthesis of 1′-CN-triazolyl-C-ribosides

Author:

Bozinovic Nina1,Aguiar Viviane Marques de2,Ferry Angélique1,Gallier Florian1ORCID,Lubin-Germain Nadège1,Uziel Jacques1,Miranda Leandro Soter de Mariz e12ORCID

Affiliation:

1. CY Cergy Paris Université, CNRS, BioCIS, 95000, Cergy-Pontoise, France

2. Biocatalysis and Organic Synthesis Group, Universidade Federal do Rio de Janeiro, Av Athos da Silveira Ramos 149, Centro de Tecnologia, Bl A, 21941909 Ilha do Fundão, Rio de Janeiro, Brazil

Abstract

Synthesis of the C1′–CN -1,2,3-triazolyl-C-ribonucleosides was achieved through the cyanation of the corresponding alkynyl-C-riboside. A new spirocyclic guanosine analogue is reported through the amination of the 1′-CN-triazolyl-C-riboside.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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