Improvement of the water solubility of tolfenamic acid by new multiple-component crystals produced by mechanochemical methods-Reference-Cited by-同舟云学术

Improvement of the water solubility of tolfenamic acid by new multiple-component crystals produced by mechanochemical methods

Published:2014 Issue:35 Volume:16 Page:8252-8262
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Gaglioti K.¹²³⁴⁵,Chierotti M. R.¹²³⁴⁵,Grifasi F.¹²³⁴⁵,Gobetto R.¹²³⁴⁵,Griesser U. J.⁶⁷⁸⁹¹⁰,Hasa D.¹¹¹²¹³,Voinovich D.¹¹¹²¹³

Affiliation:

1. Dip. di chimica

2. Fisica d dei materiali

3. Via P. Giuria

4. Torino

5. Italy

6. Institute of Pharmacy

7. Pharmaceutical Technology

8. University of Innsbruck

9. Josef-Moeller-Haus Innrain 52c

10. Innsbruck, Austria

11. Dept. of Chemical and Pharmaceutical Sciences

12. University of Trieste

13. Trieste, Italy

Abstract

Tolfenamic acid (HTA) is a drug characterized by very poor solubility in water. By mechanochemical methods, new solid-state forms of HTA were obtained, showing better thermal stability than pure HTA and an improved dissolution rate.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CE/C4CE00549J

Reference49 articles.

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