A fingerprint of amyloid plaques in a bitransgenic animal model of Alzheimer's disease obtained by statistical unmixing analysis of hyperspectral Raman data-Reference-Cited by-同舟云学术

A fingerprint of amyloid plaques in a bitransgenic animal model of Alzheimer's disease obtained by statistical unmixing analysis of hyperspectral Raman data

Published:2019 Issue:23 Volume:144 Page:7049-7056
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Fonseca Emerson A.¹²³⁴⁵,Lafetá Lucas¹²³⁴⁵,Cunha Renan¹²³⁴⁵,Miranda Hudson⁶³⁴⁵,Campos João¹²³⁴⁵^ORCID,Medeiros Helton G.⁷⁸⁹⁵,Romano-Silva Marco A.¹⁰³⁴⁵^ORCID,Silva Raigna A.¹²³⁴⁵,Barbosa Alexandre S.¹²³⁴⁵,Vieira Rafael P.¹¹³¹²⁵^ORCID,Malard Leandro M.¹²³⁴⁵^ORCID,Jorio Ado¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Física

2. ICEx

3. UFMG

4. Belo Horizonte

5. Brazil

6. Programa de Pós-Graduação em Engenharia Elétrica

7. Divisão de Metrologia de Materiais

8. Instituto Nacional de Metrologia Qualidade e Tecnologia (Inmetro)

9. Duque de Caxias

10. Departamento de Saúde Mental-Faculdade de Medicina

11. Departamento de Bioquímica e Imunologia

12. CEP 30161-70 Belo Horizonte

Abstract

We have found different Raman signatures of AB fibrils and in brain tissues from unmixed analysis, providing a detailed image of amyloid plaques in the brain, with the potential to be used as biomarkers.

Funder

Financiadora de Estudos e Projetos

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Fundação de Desenvolvimento da Pesquisa

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/AN/C9AN01631G

Reference63 articles.