Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA-Reference-Cited by-同舟云学术

Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA

Published:2022 Issue:21 Volume:4 Page:4502-4516
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Wolff Natalie¹,Kollenda Sebastian¹,Klein Kai¹,Loza Kateryna¹,Heggen Marc²,Brochhagen Leonie³,Witzke Oliver³,Krawczyk Adalbert³,Hilger Ingrid⁴^ORCID,Epple Matthias¹^ORCID

Affiliation:

1. Inorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, 45117 Essen, Germany

2. Ernst-Ruska Centre for Microscopy and Spectroscopy with Electrons, Forschungszentrum Jülich GmbH, 52428 Jülich, Germany

3. Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany

4. Department of Experimental Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, Am Klinikum 1, 07740 Jena, Germany

Abstract

Different kinds of alkyne-terminated siRNA duplexes were conjugated to azide-terminated ultrasmall gold nanoparticles (2 nm) via copper-catalyzed azide–alkyne cycloaddition, depending on the gene to be silenced.

Funder

Rudolf Ackermann Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NA/D2NA00250G

Reference113 articles.

1. Going even smaller: Engineering sub‐5 nm nanoparticles for improved delivery, biocompatibility, and functionality

2. Ultrasmall gold nanoparticles in cancer diagnosis and therapy

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