Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents-Reference-Cited by-同舟云学术

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Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Published:2015 Issue:4 Volume:6 Page:634-639
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Chau Bich Anh¹²³⁴⁵,Drummond Grant⁶⁴⁵²,Jackson W. Roy¹²³⁴⁵,Jarrott Bevyn⁷⁸²,Miller Alyson A.⁶⁴⁵²,Subasinghe Kamani R.¹²³⁴⁵,Tan Christina Y. R.⁹¹⁰⁴¹¹²,White Paul J.⁹¹⁰⁴¹¹²,Wright Christine E.¹²¹²⁸²,Ziogas James¹²¹²⁸²

Affiliation:

1. ARC Centre for Free Radical Chemistry & Biotechnology

2. Australia

3. Centre for Green Chemistry

4. Monash University

5. Clayton

6. Department of Pharmacology

7. The Florey Institute of Neuroscience and Mental Health

8. The University of Melbourne

9. Medicinal Chemistry and Drug Action

10. Monash Institute of Pharmaceutical Sciences

11. Parkville

12. Department of Pharmacology & Therapeutics

Abstract

Some mexiletine derivatives with isoindoline based antioxidants attached have been shown to have significant cardioprotective properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00459K

Reference28 articles.

1. E. M. Vaughan Williams , in Advances in Drug Research, ed. N. J. Harper and A. B. Simmonds, Academic Press, London, 1974, vol. 9, pp. 69–101

2. Classification and pharmacology of antiarrhythmic drugs

3. Cardioprotective Effect of Mexiletine in Acute Myocardial Ischemia. Studies in the Rabbit Closed Chest Ischemia Model.

4. Mexiletine Protects Myocardium During Acute Ischemia by Opening Sarcolemmal K-ATP Channel

5. New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamides.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Potentiality and Synthesis of O- and N-Heterocycles: Pd-Catalyzed Cyclocarbonylative Sonogashira Coupling as a Valuable Route to Phthalans, Isochromans, and Isoindolines;European Journal of Organic Chemistry;2017-10-24

2. Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride;Tetrahedron Letters;2015-09

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