Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives

Author:

Busch Torsten1234,Dräger Gerald1234,Kunst Eike1234,Benson Hannah1234,Sasse Florenz564,Siems Karsten784,Kirschning Andreas1234

Affiliation:

1. Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ)

2. Leibniz Universität Hannover

3. 30167 Hannover

4. Germany

5. Helmholtz Zentrum für Infektionsforschung (HZI)

6. 38124 Braunschweig

7. AnalytiCon Discovery GmbH

8. 14473 Potsdam

Abstract

The synthesis, determination of cytotoxic properties and phenotype visualisation during mitosis of tonantzitlolone A and 18 derivatives is reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference23 articles.

1. Tonantzitlolone and other Diterpenes fromStillingia sanguinolenta

2. C. F. Millspaugh , American Medicinal Plants, Dover Publications Inc., New York, 1974, p. 811

3. D. E. Moerman , Medicinal Plants of Native America, University of Michigan, Museum of Antropology, Ann Arbor, 1986

4. Constituintes químicos de Sebastiania macrocarpa Muell. Arg. (Euphorbiaceae)

5. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

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