Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1-Reference-Cited by-同舟云学术

Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1

Published:2015 Issue:46 Volume:13 Page:11315-11330
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tommasi Sara¹²³⁴⁵,Zanato Chiara¹²³⁴⁵,Lewis Benjamin C.⁶⁷⁸⁹,Nair Pramod C.⁶⁷⁸⁹,Dall'Angelo Sergio¹²³⁴⁵,Zanda Matteo¹²³⁴⁵,Mangoni Arduino A.⁶⁷⁸⁹

Affiliation:

1. Kosterlitz Centre for Therapeutics

2. Institute of Medical Sciences

3. School of Medical Sciences

4. University of Aberdeen

5. Aberdeen AB25 2ZD

6. Department of Clinical Pharmacology

7. School of Medicine

8. Flinders University and Flinders Medical Centre

9. Australia

Abstract

Arginine analogues incorporating carboxylate bioisosteric functional groups exhibit low micromolar inhibitory potential against human dimethylarginine dimethylaminohydrolase (DDAH), a key enzyme in the nitric oxide pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01843A

Reference65 articles.

1. Blocking NO synthesis: how, where and why?

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3. Nitric Oxide in the Vasculature: Physiology and Pathophysiology

4. Nitric Oxide and Atherosclerosis

5. Nitric oxide and the immune response

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