Engineering P450LaMO stereospecificity and product selectivity for selective C–H oxidation of tetralin-like alkylbenzenes-Reference-Cited by-同舟云学术

Engineering P450LaMO stereospecificity and product selectivity for selective C–H oxidation of tetralin-like alkylbenzenes

Published:2018 Issue:18 Volume:8 Page:4638-4644
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Li Ren-Jie¹²³⁴⁵^ORCID,Li Aitao⁶⁷⁸⁹¹⁰,Zhao Jing¹¹¹²¹³⁵,Chen Qi¹²³⁴⁵,Li Ning¹⁴¹⁵¹⁶¹⁷¹⁸^ORCID,Yu Hui-Lei¹²³⁴⁵,Xu Jian-He¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. Shanghai Collaborative Innovation Center for Biomanufacturing

3. East China University of Science and Technology

4. Shanghai 200237

5. P. R. China

6. Hubei Collaborative Innovation Center for Green Transformation of Bio-resources

7. Hubei Key Laboratory of Industrial Biotechnology

8. College of Life Sciences

9. Hubei University

10. Wuhan 430062

11. Tianjin Institute of Industrial Biotechnology

12. Chinese Academy of Sciences

13. Tianjin 300308

14. State Key Laboratory of Pulp and Paper Engineering

15. College of Light Industry and Food Sciences

16. South China University of Technology

17. Guangzhou

18. China

Abstract

Via Phe scanning based protein engineering, P450_LaMO increased enantioselectivity to er 98 : 2 and product selectivity, alcohol : ketone, to ak 99 : 1.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01448E

Reference75 articles.

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