A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies-Reference-Cited by-同舟云学术

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A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies

Published:2018 Issue:10 Volume:42 Page:8050-8061
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Cappai Rosita¹²³⁴⁵,Chand Karam¹²³⁴⁵,Lachowicz Joanna I.⁶⁷⁸⁹¹⁰,Chaves Sílvia¹²³⁴⁵^ORCID,Gano Lurdes¹¹²³¹²⁵^ORCID,Crisponi Guido⁶⁷⁸⁹¹⁰^ORCID,Nurchi Valeria M.⁶⁷⁸⁹¹⁰^ORCID,Peana Massimiliano¹³¹⁴¹⁵¹⁰^ORCID,Zoroddu Maria Antonietta¹³¹⁴¹⁵¹⁰,Santos M. Amélia¹²³⁴⁵^ORCID

Affiliation:

1. Centro de Química Estrutural

2. Instituto Superior Técnico

3. Universidade de Lisboa

4. 1049-001 Lisboa

5. Portugal

6. Dipartimento di Scienze Chimiche e Geologiche

7. Università di Cagliari

8. Cittadella Universitaria

9. 09042 Monserrato-Cagliari

10. Italy

11. Centro de Ciências e Tecnologias Nucleares (C2TN)

12. 2695-066 Bobadela LRS

13. Dipartimento di Chimica e Farmacia

14. Università di Sassari

15. 07100 Sassari

Abstract

A new highly efficient tris-hydroxypyridinone chelator for iron and aluminum, with promising capacity as a potential metal decorporation agent.

Funder

Fundação para a Ciência e a Tecnologia

Università di Cagliari

Ministero dell'Istruzione, dell'Università e della Ricerca

Fondazione Banco di Sardegna

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ00116B

Reference47 articles.

1. The hazards of iron loading

2. Human diseases related to aluminium overload

3. T. Kiss , K.Gajda-Schrantz and P.Zatta , The role of aluminium in neurotoxic and neurodegenerative processes , in Metal Ions and Life Sciences, Neurodegenerative Diseases and Metal Ions , ed. A. Sigel , H. Sigel and R. K. O. Sigel , Wiley & Sons , Chichester , 2006 , vol. I, p. 371

4. A molecular mechanism of aluminium-induced Alzheimer's disease?

5. The Prevalence of Bone Aluminum Deposition in Renal Osteodystrophy and Its Relation to the Response to Calcitriol Therapy

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