Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay-Reference-Cited by-同舟云学术

Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Margiola Sofia¹²³⁴,Gerecht Karola¹²³⁴,Müller Manuel M.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. King's College London

3. London

4. UK

Abstract

‘Designer’ p53: semi-synthesis of the tumor suppressor protein p53 via native chemical ligation enables in vitro structure–activity studies to reveal how this master regulator of cell fate is itself regulated by phosphorylation.

Funder

Wellcome Trust

Royal Society

King's College London

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00396H

Reference53 articles.

1. Putting p53 in Context

2. Transcriptional Regulation by P53

3. TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

4. Structural Biology of the Tumor Suppressor p53

5. Posttranslational Modification of p53: Cooperative Integrators of Function

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