In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-MPro inhibitors

Author:

Aljuhani Ateyatallah1,Ahmed Hany E. A.23,Ihmaid Saleh K.24,Omar Abdelsattar M.567,Althagfan Sultan S.8,Alahmadi Yaser M.8ORCID,Ahmad Iqrar9,Patel Harun9,Ahmed Sahar210,Almikhlafi Mohannad A.11,El-Agrody Ahmed M.12,Zayed Mohamed F.713,Turkistani Safaa Abdulrahman13,Abulkhair Shorouk H.14ORCID,Almaghrabi Mohammed2,Salama Samir A.15,Al-Karmalawy Ahmed A.16ORCID,Abulkhair Hamada S.316ORCID

Affiliation:

1. Chemistry Department, College of Sciences, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia

2. Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia

3. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt

4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Jadara University, Irbid, Jordan

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia

6. Center for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt

8. Clinical and Hospital Pharmacy Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia

9. Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Maharashtra, India

10. Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assuit, Egypt

11. Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia

12. Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

13. Pharmaceutical Sciences Department, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

14. Department of Biochemistry, Faculty of Medicine, Al-Azhar University (Girls), Nasr City 11754, Cairo, Egypt

15. Division of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

16. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University – Egypt, International Coastal Road, New Damietta 34518, Egypt

Abstract

An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro).

Funder

Taif University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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