Discovery of indolizine lactones as anticancer agents and their optimization through late-stage functionalization-Reference-Cited by-同舟云学术

Discovery of indolizine lactones as anticancer agents and their optimization through late-stage functionalization

Published:2023 Issue:29 Volume:13 Page:20264-20270
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

da Silva Thiago Sabino¹^ORCID,da Silva Souza Matheus²^ORCID,Andricopulo Adriano Defini²,Coelho Fernando¹^ORCID

Affiliation:

1. Laboratory of Synthesis of Natural Products and Drugs, Institute of Chemistry, University of Campinas, Rua Monteiro Lobato, S/N, 13083-970, Campinas, São Paulo, Brazil

2. Laboratory of Medicinal and Computational Chemistry, Institute of Physics of Sao Carlos, University of Sao Paulo – Avenida Joao Dagnone, 1100-13563-120 – Sao Carlos, SP, Brazil

Abstract

Indolizines fused with a seven-membered ring were identified as promising anticancer scaffolds and had their cytotoxicity increased up to twenty times by late-stage functionalization.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA03395C

Reference40 articles.

1. Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines