Membrane targeting enhances muramyl dipeptide binding to NOD2 and Arf6–GTPase in mammalian cells-Reference-Cited by-同舟云学术

Membrane targeting enhances muramyl dipeptide binding to NOD2 and Arf6–GTPase in mammalian cells

Published:2022 Issue:46 Volume:58 Page:6598-6601
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hespen Charles W.¹^ORCID,Zhao Xiaohui²^ORCID,Hang Howard C.²

Affiliation:

1. Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA

2. Department of Immunology and Microbiology and Department of Chemistry, Scripps Research, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA

Abstract

Membrane localization of each component strengthens NOD2–MDP–Arf6 binding, demonstrating importance of membrane targeting for future NOD2 agonist design.

Funder

National Center for Complementary and Integrative Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01903E

Reference32 articles.

1. NOD proteins: regulators of inflammation in health and disease

2. Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

3. Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2

4. Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

5. NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

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