Self-organized environment-sensitive inulin–doxorubicin conjugate with a selective cytotoxic effect towards cancer cells-Reference-Cited by-同舟云学术

Self-organized environment-sensitive inulin–doxorubicin conjugate with a selective cytotoxic effect towards cancer cells

Published:2015 Issue:41 Volume:5 Page:32421-32430
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mauro N.¹²³⁴⁵,Campora S.⁶⁴⁷⁸,Scialabba C.¹²³⁴⁵,Adamo G.⁶⁴⁷⁸,Licciardi M.¹²³⁴⁵,Ghersi G.⁶⁴⁷⁸,Giammona G.¹²³⁴⁵

Affiliation:

1. Laboratory of Biocompatible Polymers

2. Department of “Scienze e Tecnologie Biologiche

3. Chimiche e Farmaceutiche” (STEBICEF)

4. University of Palermo

5. 32 90123 Palermo

6. Department of “Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche” (STEBICEF)

7. 16 90128 Palermo

8. Italy

Abstract

An inulin-based copolymer bearing high dose doxorubicin (18.45 % w/w), INU-EDA-P,C-DOXO, was prepared by coupling doxorubicin with inulin though citraconylamide bridge used as pH sensitive spacer. Its smart and selective anticancer effect was proved.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA00287G

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