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Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes

  • Published:2024 Issue:3 Volume:22 Page:590-605
  • ISSN:1477-0520
  • Container-title:Organic & Biomolecular Chemistry
  • language:en
  • Short-container-title:Org. Biomol. Chem.

Author:

Forshaw Sam1ORCID,Parker Jeremy S.2ORCID,Scott William T.13ORCID,Knighton Richard C.14ORCID,Tiwari Neelam1,Oladeji Samson M.1,Stevens Andrew C.1,Chew Yean Ming13ORCID,Reber Jami1ORCID,Clarkson Guy J.1ORCID,Balasubramanian Mohan K.3,Wills Martin1ORCID

Affiliation:

1. Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK

2. Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, SK10 2NA, UK

3. Warwick Medical School, The University of Warwick, Coventry, CV4 7AL, UK

4. School of Chemistry, University of Southampton, SO17 1BJ, UK

Abstract

Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free ‘click’ reactions.

Funder

Engineering and Physical Sciences Research Council

AstraZeneca

Advantage West Midlands

European Regional Development Fund

Medical Research Council

Commonwealth Scholarship Commission

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
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