Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4 + 3) cyloaddition reactions of aza-oxyallylic cation intermediates-Reference-Cited by-同舟云学术

Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4 + 3) cyloaddition reactions of aza-oxyallylic cation intermediates

Published:2016 Issue:3 Volume:3 Page:330-334
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Acharya A.¹²³²⁴,Eickhoff J. A.⁵⁶⁷⁴,Chen K.¹²³²⁴,Catalano V. J.¹²³²⁴,Jeffrey C. S.¹²³²⁴^ORCID

Affiliation:

1. University of Nevada

2. Reno

3. Department of Chemistry

4. USA

5. Department of Chemistry & Biochemistry

6. University of California Santa Barbara

7. Santa Barbara

Abstract

The intramolecular aza-(4 + 3) cycloaddition reactions of in situ generated aza-oxyallylic cations and furans have been reported for the construction of medium sized hydroxamate macrocycles.

Funder

American Chemical Society Petroleum Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/QO/C5QO00315F

Reference44 articles.

1. The exploration of macrocycles for drug discovery — an underexploited structural class

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4. Aiming for the Ideal Synthesis

5. Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization

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