Cordyceps sinensis-mediated biotransformation of notoginsenoside R1 into 25-OH-20(S/R)-R2 with elevated cardioprotective effect against DOX-induced cell injury-Reference-Cited by-同舟云学术

Cordyceps sinensis-mediated biotransformation of notoginsenoside R1 into 25-OH-20(S/R)-R2 with elevated cardioprotective effect against DOX-induced cell injury

Published:2022 Issue:21 Volume:12 Page:12938-12946
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Jishuang¹^ORCID,Xin Yu¹,Qiu Zhidong¹,Zhang Qi¹,He Tianzhu²,Qiu Ye¹,Wang Weinan¹^ORCID

Affiliation:

1. School of pharmaceutical sciences, Changchun University of Chinese Medicine, Changchun, Jilin Province, China

2. School of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin Province, China

Abstract

The biocatalytic system in this paper preferably yielded 25-OH notoginsenoside R2 from R1 in a regioselective manner. Such a process significantly elevated the effects of these 25-OH derivatives against DOX-induced cardiomyocyte injury.

Funder

Education Department of Jilin Province

Department of Science and Technology of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA01470J

Reference44 articles.

1. Phytochemistry, pharmacology, and clinical use of Panax notoginseng flowers buds

2. Notoginsenoside R1 for Organs Ischemia/Reperfusion Injury: A Preclinical Systematic Review

3. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

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