Investigating the solubilization effect of oxcarbazepine by forming cocrystals-Reference-Cited by-同舟云学术

Investigating the solubilization effect of oxcarbazepine by forming cocrystals

Published:2019 Issue:32 Volume:21 Page:4718-4729
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Li Xiangrong¹²³⁴,Yu Guojia¹²³⁴,Chen Xinjian¹²³⁴,He Lichao¹²³⁴,Zhou Zhiyong¹²³⁴^ORCID,Ren Zhongqi¹²³⁴^ORCID

Affiliation:

1. College of Chemical Engineering

2. Beijing University of Chemical Technology

3. Beijing 100029

4. People's Republic of China

Abstract

Oxcarbazepine (OXCBZ) is a poorly soluble drug that can't form a salt. The apparent solubilities of the OXCBZ–OA and OXCBZ–2,5-DHBA cocrystals increased approximately 2.6 and 4.7 times of that of OXCBZ.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CE/C9CE00651F

Reference33 articles.

1. Pharmaceutical cocrystals: along the path to improved medicines

2. Perphenazine–fumaric acid salts with improved solubility: preparation, physico-chemical characterization and in vitro dissolution

3. Polymeric prodrug of bufalin for increasing solubility and stability: Synthesis and anticancer study in vitro and in vivo

4. Improvement in solubility of poor water-soluble drugs by solid dispersion

5. Rational Analysis of Melting Point Behavior of Co-Crystals of 4-Nitrophenol with Some Aza-Compounds

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Environmentally Friendly High-Energy Oxidizers for Solid Rocket Propellants;Space Technology Library;2024

2. The enhanced pH-dependent solubility behavior of three novel lamotrigine-acid salts;Journal of Molecular Liquids;2023-07

3. New Chrysin-based co-crystals: Synthesis, characterization and dissolution studies;Journal of Molecular Structure;2023-01

4. Recent Advances on the Biological Study of Pharmaceutical Cocrystals;AAPS PharmSciTech;2022-11-17

5. Synthesis and dissolution behaviour of nateglinide‐nicotinamide cocrystals by simple slurry crystallization;The Canadian Journal of Chemical Engineering;2022-11-02