Solvent-free synthesis and in-silico molecular docking study of (E)-3-(β-C-glycosylmethylidene)-N-aryl/alkyl succinimides-Reference-Cited by-同舟云学术

Solvent-free synthesis and in-silico molecular docking study of (E)-3-(β-C-glycosylmethylidene)-N-aryl/alkyl succinimides

Published:2023 Issue:47 Volume:21 Page:9398-9409
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shankar Bhawani¹²^ORCID,Singh Tejveer³,Kumar Banty⁴,Arora Aditi²,Kumar Sumit²,Singh Brajendra K.²^ORCID

Affiliation:

1. Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-110019, India

2. Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India

3. Department of Zoology, Hansraj College, University of Delhi, Delhi-110007, India

4. Department of Chemistry, Rajdhani College, University of Delhi, Delhi-110015, India

Abstract

Solvent-free synthesis of β-C-glycosylated methylidene succinimides using the Wittig olefination reaction and subsequent Lewis acid-mediated deprotection has been reported. Docking studies reveal that these compounds are selective and potent inhibitors of the E6 oncoprotein of high-risk type HPV16.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01252B

Reference44 articles.

1. Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects

2. Human papillomavirus as a driver of head and neck cancers

3. Human papilloma virus in oral cancer

4. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

5. Therapeutic startegies for human papillomavirus infection and associated cancers

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