Matrix metalloproteinase responsive hydrogel microplates for programmed killing of invasive tumour cells

Author:

Cook Alexander B.1ORCID,Palange Annalisa1,Schlich Michele1ORCID,Bellotti Elena1,Brahmachari Sayanti1,di Francesco Martina1,Decuzzi Paolo1

Affiliation:

1. Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego, 16163 Genova, Italy

Abstract

Hydrogel microplates are formed through photoinitiated thiol–ene chemistry in a soft-lithography process, leading to enzyme responsive drug nanoparticle release to MMP-2/9 expressing brain cancer cell line U87-MG.

Funder

European Research Council

HORIZON EUROPE Marie Sklodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

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