Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage-Reference-Cited by-同舟云学术

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Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage

Published:2016 Issue:33 Volume:45 Page:13179-13186
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Pracharova Jitka¹²³⁴⁵,Radosova Muchova Tereza¹⁶³⁷⁵,Dvorak Tomastikova Eva⁸²⁹⁵,Intini Francesco P.¹⁰¹¹¹²¹³,Pacifico Concetta¹⁰¹¹¹²¹³,Natile Giovanni¹⁰¹¹¹²¹³,Kasparkova Jana¹⁶³⁷⁵,Brabec Viktor¹⁴¹⁵¹⁶⁵

Affiliation:

1. Department of Biophysics

2. Centre of the Region Haná for Biotechnological and Agricultural Research

3. Palacký University

4. 783 41 Olomouc

5. Czech Republic

6. Faculty of Science

7. CZ-78371 Olomouc

8. Institute of Experimental Botany

9. 78371 Olomouc

10. Department of Chemistry

11. University of Bari “Aldo Moro”

12. 70125 Bari

13. Italy

14. Institute of Biophysics

15. Academy of Sciences of the Czech Republic

16. CZ-61265 Brno

Abstract

Photoinduced DNA damage by trans-[PtCl₂(NH₃)(1-methyl-7-azaindole)] is related to its photocytotoxic activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT01467D

Reference38 articles.

1. The status of platinum anticancer drugs in the clinic and in clinical trials

2. Modifications of DNA by platinum complexes

3. The resurgence of platinum-based cancer chemotherapy

4. Anti-tumour platinum complexes : relationships between chemical properties and activity

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