Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases-Reference-Cited by-同舟云学术

Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

Published:2021 Issue:1 Volume:12 Page:95-102
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Qian Kun¹²³⁴⁵^ORCID,Yan Chunli⁶⁷⁸⁵,Su Hairui⁹¹⁰¹¹⁵,Dang Tran¹²³⁴⁵,Zhou Bo¹²³⁴⁵,Wang Zhenyu⁶⁷⁸⁵,Zhao Xinyang⁹¹⁰¹¹⁵,Ivanov Ivaylo⁶⁷⁸⁵,Ho Meng-Chiao¹²¹³¹⁴¹⁵,Zheng Y. George¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences

2. College of Pharmacy

3. University of Georgia

4. Athens

5. USA

6. Department of Chemistry and Center for Diagnostics and Therapeutics

7. Georgia State University

8. Atlanta

9. Department of Biochemistry and Molecular Genetics

10. The University of Alabama at Birmingham

11. Birmingham

12. Institute of Biological Chemistry

13. Academia Sinica

14. Taipei

15. Taiwan

Abstract

A new diamidine compound was identified as a potent PRMT1 inhibitor that blocked leukaemia cell proliferation and decreased arginine asymmetric dimethylation.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00259C

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