Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity-Reference-Cited by-同舟云学术

Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity

Published:2020 Issue:11 Volume:8 Page:2256-2268
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Li Xi¹²³⁴⁵,Wang Wenjuan¹²³⁴⁵,Dong Xiaoyan¹²³⁴⁵,Sun Yan¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education

2. School of Chemical Engineering and Technology

3. Tianjin University

4. Tianjin 300354

5. China

Abstract

Conjugation of alkaline decapeptide (RTHLVFFARK) to lysozyme creates a potent multifunctional modulator (R-hLys) for Cu²⁺-mediated amyloid β-protein aggregation and cytotoxicity.

Funder

Natural Science Foundation of Tianjin City

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/C9TB02397F

Reference60 articles.

1. Protein aggregation and neurodegenerative disease

2. A Century of Alzheimer's Disease