Insights into the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-induced gelation of fully carboxylated collagen and the fabrication of hydrogels with enhanced mechanical properties

Author:

Zhang Juntao1,Xu Haofei1,Liu Yang1,Sui Peishan1,Deng Fen1,Zheng Mingming12ORCID,Liu Tianyi1,Wei Benmei1,Xu Chengzhi1,Wang Haibo3ORCID

Affiliation:

1. School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, Hubei, China

2. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Wuhan, Hubei, China

3. College of Life Science and Technology, Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, Xiaogan, Hubei, China

Abstract

EDC-induced gelation of succinylated collagen with a high concentration was realized, and its triple helix structure is crucial for this process. G′ of succinylated collagen hydrogel was improved to 310 Pa compared to 20 Pa of the collagen hydrogel.

Funder

National Natural Science Foundation of China

Wuhan Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

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