Molecular bowls for inclusion complexation of toxic anticancer drug methotrexate-Reference-Cited by-同舟云学术

Molecular bowls for inclusion complexation of toxic anticancer drug methotrexate

Published:2024 Issue:26 Volume:15 Page:10155-10163
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Karmakar Pratik¹²,Finnegan Tyler J.¹,Rostam Darian C.¹,Taneja Sagarika¹,Uçar Sefa¹³,Hansen Alexandar L.⁴,Moore Curtis E.¹,Hadad Christopher M.¹^ORCID,Pratumyot Kornkanya²,Parquette Jon R.¹,Badjić Jovica D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA

2. Supramolecular Chemistry Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, 126 Pracha Uthit Road, Bang Mod, Thung Khru, Bangkok 10140, Thailand

3. Atatürk University, Faculty of Science, Department of Chemistry, Erzurum 25240, Turkey

4. Campus Chemical Instrumentation Center, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA

Abstract

We describe synthesis, conformational dynamics and assembly characteristics of novel and tribenzotriquinacene-based hosts in water. These biocompatible molecules form stable inclusion complexes with toxic and anticancer drug methotrexate.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05627A

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