β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates-Reference-Cited by-同舟云学术

β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates

Published:2021 Issue:10 Volume:12 Page:1623-1639
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mora-Ochomogo Montserrat¹^ORCID,Lohans Christopher T.¹^ORCID

Affiliation:

1. Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada

Abstract

Overview of β-lactam antibiotics and the proteins with which they covalently interact, focusing on penicillin-binding proteins and serine β-lactamases.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00200G

Reference186 articles.

1. β-Lactams and β-Lactamase Inhibitors: An Overview

2. M. G.Page , in Antibiotic Discovery and Development , ed. T. J. Dougherty and M.J. Pucci , Springer , New York , 2012 , pp. 79–117

3. A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis

4. A functional classification scheme for beta-lactamases and its correlation with molecular structure

5. Metallo-β-lactamase structure and function

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