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Induction of potent apoptosis by an anti-CD20 aptamer via the crosslink of membrane CD20 on non-Hodgkin's lymphoma cells

  • Published:2017 Issue:9 Volume:7 Page:5158-5166
  • ISSN:2046-2069
  • Container-title:RSC Advances
  • language:en
  • Short-container-title:RSC Adv.

Author:

Wu Cong1234,Wan Wei56734,Zhu Ji1234,Jin Hai1234,Zhao Tiejun1234,Li Huafei12348ORCID

Affiliation:

1. Department of Laboratory Diagnosis/Thoracic Surgery

2. Changhai Hospital Affiliated to the Second Military Medical University

3. Shanghai

4. P.R. China

5. Department of Orthopedic Oncology

6. Spine Tumor Center

7. Changzheng Hospital Affiliated to the Second Military Medical University

8. International Joint Cancer Institute

Abstract

An anti-CD20 DNA aptamer was successfully generated by cell-SELEX, the crosslink of which can induce potent apoptosis in target cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry
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