Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed γ-C(sp3)–H activation for peptide preparation-Reference-Cited by-同舟云学术

Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed γ-C(sp3)–H activation for peptide preparation

Published:2019 Issue:8 Volume:17 Page:2099-2102
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Duan Hua-Zhen¹²³⁴⁵,Chen Hong-Xue¹²³⁴⁵,Yu Qing¹²³⁴⁵,Hu Jun¹²³⁴⁵,Li Yan-Mei¹²³⁴⁵^ORCID,Chen Yong-Xiang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education)

2. Department of Chemistry

3. Tsinghua University

4. Beijing 100084

5. China

Abstract

We report a facile and efficient synthetic strategy toward a CH₂-substituted phosphonate pThr mimetic and its application in phosphopeptide inhibitor synthesis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02999G

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