From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors-Reference-Cited by-同舟云学术

From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors

Published:2019 Issue:4 Volume:17 Page:916-929
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Pastor Miryam¹²³⁴⁵,Zapico José María¹²³⁴⁵^ORCID,Coderch Claire¹²³⁴⁵^ORCID,Maslyk Maciej⁶⁷⁸⁹¹⁰^ORCID,Panchuk Rostyslav¹¹¹²¹³¹⁴^ORCID,de Pascual-Teresa Beatriz¹²³⁴⁵^ORCID,Ramos Ana¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química y Bioquímica

2. Facultad de Farmacia

3. Universidad San Pablo-CEU

4. CEU Universities

5. Madrid

6. Department of Molecular Biology

7. Faculty of Biotechnology and Environment Sciences

8. The John Paul II Catholic University of Lublin

9. Lublin

10. Poland

11. Institute of Cell Biology

12. NAS of Ukraine

13. Lviv

14. Ukraine

Abstract

In this article, we describe new MMP13 inhibitors, active at low nanomolar concentrations, and with a novel TBB-derived scaffold.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02990C

Reference50 articles.

1. Matrix metalloproteinases and the regulation of tissue remodelling

2. MMPs as therapeutic targets—Still a viable option?

3. Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

4. Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

5. Strategies for MMP inhibition in cancer: innovations for the post-trial era

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