Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

Author:

Lee Dong-yup1ORCID,Amirthalingam Sivashanmugam12ORCID,Lee Changyub1ORCID,Rajendran Arun Kumar1ORCID,Ahn Young-Hyun13ORCID,Hwang Nathaniel S.1432ORCID

Affiliation:

1. School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea

2. Institute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea

3. Bio-MAX/N-Bio Institute, Institute of Bio-Engineering, Seoul National University, Seoul, 08826, Republic of Korea

4. Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea

Abstract

This review article discusses the latest formulation methodologies and strategies for the targeted delivery of lipid nanoparticles and cell-derived nanovesicles to achieve efficient gene transfection with minimized side effects.

Funder

National Research Foundation of Korea

Ministry of Science and ICT, South Korea

Ministry of Health and Welfare

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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