The key role of the latent N–H group in Milstein's catalyst for ester hydrogenation-Reference-Cited by-同舟云学术

The key role of the latent N–H group in Milstein's catalyst for ester hydrogenation

Published:2021 Issue:24 Volume:12 Page:8477-8492
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Pham John¹²³⁴^ORCID,Jarczyk Cole E.¹²³⁴^ORCID,Reynolds Eamon F.¹²³⁴^ORCID,Kelly Sophie. E.¹²³⁴^ORCID,Kim Thao¹²³⁴^ORCID,He Tianyi¹²³⁴^ORCID,Keith Jason M.¹²³⁴^ORCID,Chianese Anthony R.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Colgate University

3. New York 13346

4. USA

Abstract

We report a detailed mechanistic study of ester hydrogenation catalyzed by the activated form of Milstein’s catalyst. Catalyst activation leads to the replacement of a dialkylamino side group with an NHEt group, which has a key role in catalysis.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00703C

Reference97 articles.

1. Efficient Homogeneous Catalytic Hydrogenation of Esters to Alcohols

2. Facile Conversion of Alcohols into Esters and Dihydrogen Catalyzed by New Ruthenium Complexes

3. Direct Synthesis of Amides from Alcohols and Amines with Liberation of H 2