Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in a RCCS facilitates locomotor functional recovery in spinal cord injury animals

Author:

Zou Yunlong1,Yin Yanyun2,Xiao Zhifeng2,Zhao Yannan2,Han Jin2,Chen Bing2,Xu Bai2,Cui Yi3,Ma Xu3,Dai Jianwu2ORCID

Affiliation:

1. China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China

2. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100101, China

3. Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China

Abstract

The better therapeutic effect of 3D NSCs cultured in a RCCS for the treatment of SCI was verified, indicating that RCCS has promising application in producing tissue engineered seed cells for future clinical treatment.

Funder

National Key Research and Development Program of China

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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