Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe-Reference-Cited by-同舟云学术

Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe

Published:2020 Issue:34 Volume:56 Page:4640-4643
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li Lu¹²³⁴⁵,Feng Lei⁵⁶⁷⁸⁴^ORCID,Zhang Ming⁵⁶⁷⁸⁴,He Xin⁵⁶⁷⁸⁴,Luan Shengqiao⁵⁶⁷⁸⁴,Wang Chao⁵⁶⁷⁸⁴^ORCID,James Tony D.⁹¹⁰¹¹¹²^ORCID,Zhang Houli⁵⁶⁷⁸⁴,Huang Huilian¹³¹⁴¹⁵¹⁶⁴,Ma Xiaochi¹²³⁴^ORCID

Affiliation:

1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy

2. Xuzhou Medical University

3. Xuzhou 221004

4. China

5. College of Pharmacy, Academy of Integrative Medicine

6. The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease

7. Dalian Medical University

8. Dalian 116044

9. Department of Chemistry

10. University of Bath

11. Bath BA2 7AY

12. UK

13. Laboratory of Modern Preparation of TCM

14. Ministry of Education

15. Jiangxi University of Traditional Chinese Medicine

16. Nanchang 330004

Abstract

A ratiometric fluorescent probe (PNA) has been developed to sense and image bacterial penicillin G acylase in addition to the high-throughput screening of PGA inhibitors.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC00197J

Reference30 articles.

1. Penicillin acylases revisited: importance beyond their industrial utility

2. Purification and characterization of YxeI, a penicillin acylase from Bacillus subtilis

3. Efficient enzymatic synthesis of ampicillin using mutant Penicillin G acylase with bio-based solvent glycerol

4. Efficient synthesis of β-lactam antibiotics with very low product hydrolysis by a mutant Providencia rettgeri penicillin G acylase

5. Structural and Functional Analysis of a Conjugated Bile Salt Hydrolase from Bifidobacterium longum Reveals an Evolutionary Relationship with Penicillin V Acylase

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