Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids-Reference-Cited by-同舟云学术

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Published:2015 Issue:36 Volume:51 Page:7626-7628
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kellner Franziska¹²³⁴,Geu-Flores Fernando⁵⁶⁷⁸⁹,Sherden Nathaniel H.¹²³⁴,Brown Stephanie¹²³⁴,Foureau Emilien¹⁰¹¹¹²¹³,Courdavault Vincent¹⁰¹¹¹²¹³,O'Connor Sarah E.¹²³⁴

Affiliation:

1. Department of Biological Chemistry

2. The John Innes Centre

3. Norwich

4. UK

5. Copenhagen Plant Science Centre and Section for Plant Biochemistry

6. Department of Plant and Environmental Sciences

7. University of Copenhagen

8. Frederiksberg

9. Denmark

10. Université François Rabelais de Tours

11. EA2106 “Biomolécules et Biotechnologies Végétales”

12. 37200 Tours

13. France

Abstract

A cytochrome P450, 16T3O, that catalyzes a key step in vinblastine biosynthesis has been discovered.

Funder

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC01309G

Reference25 articles.

1. Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analog: solvent effect on the stereochemistry of the crucial C-15/C-18' bond

2. Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase

3. Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase

4. Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis

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