Fluorescence enhancement and pKa shift of a rho kinase inhibitor by a synthetic receptor
Author:
Affiliation:
1. State Key Laboratory of Quality Research in Chinese Medicine
2. Institute of Chinese Medical Sciences
3. University of Macau
4. Taipa
5. China
6. Aix Marseille Univ
7. CNRS
8. ICR
9. Marseille
10. France
Abstract
The significant fluorescence enhancement and pKa shift of fasudil upon encapsulation by cucurbit[7]uril may provide a traceable enteric formulation.
Funder
Fundo para o Desenvolvimento das Ciências e da Tecnologia
Universidade de Macau
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00547D
Reference49 articles.
1. Rho kinase, a promising drug target for neurological disorders
2. Inhibition of Neutrophil Migration by a Protein Kinase Inhibitor for the Treatment of Ischemic Brain Infarction
3. Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity
4. Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
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