Osmium(ii) tethered half-sandwich complexes: pH-dependent aqueous speciation and transfer hydrogenation in cells-Reference-Cited by-同舟云学术

Osmium(ii) tethered half-sandwich complexes: pH-dependent aqueous speciation and transfer hydrogenation in cells

Published:2021 Issue:27 Volume:12 Page:9287-9297
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Infante-Tadeo Sonia¹²³^ORCID,Rodríguez-Fanjul Vanessa¹²³^ORCID,Habtemariam Abraha¹²³⁴⁵^ORCID,Pizarro Ana M.¹²³⁶²^ORCID

Affiliation:

1. IMDEA Nanociencia

2. 28049 Madrid

3. Spain

4. Department of Chemistry

5. University of Warwick

6. Unidad Asociada de Nanobiotecnología CNB-CSIC-IMDEA

Abstract

New Os(ii) half-sandwich complexes bearing a pendant alcohol prompt reversible tether-ring formation upon aquation, protecting Os against deactivation. Excitingly, these complexes mediate hydrogenation of pyruvate to lactate inside cancer cells.

Funder

Comunidad de Madrid

FP7 People: Marie-Curie Actions

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01939B

Reference87 articles.

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