A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe-Reference-Cited by-同舟云学术

A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

Published:2020 Issue:21 Volume:18 Page:4029-4033
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Jie¹²³⁴⁵,Xu Weipan¹²³⁴⁵,Xue Shuyuan¹²³⁴⁵,Yu Tao¹²³⁴⁵,Xie Hexin¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. Shanghai Key Laboratory of New Drug Design

3. School of Pharmacy

4. East China University of Science and Technology

5. Shanghai 200237

Abstract

A carbapenem-based fluorogenic reagent has been developed to detect the activity of carbapenemases, exhibiting high specificity to all carbapenemases, including both metallo carbapenemases and serine carbapenemases, over other β-lactamases.

Funder

National Natural Science Foundation of China

State Key Laboratory of Bioreactor Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00114G

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