Synthesis and antiproliferative activity of 6-naphthylpterocarpans
Author:
Affiliation:
1. Department of Organic Chemistry
2. University of Debrecen
3. 4002 Debrecen
4. Hungary
5. Doctoral School of Chemistry
6. Department of Physiology
7. Faculty of Medicine
8. Debrecen
9. Department of Immunology
Abstract
The Heck-oxyarylation of 2H-chromenes afforded (6S*,6aR*,11aR*)-6-naphthylpterocarpans with potent antiproliferative activity. Absolute configurations and conformations of the separated enantiomers were determined by TDDFT-ECD calculations.
Funder
Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
European Commission
European Regional Development Fund
Magyar Tudományos Akadémia
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00110D
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